Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (881)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Controls (9) Inhibitors (540) Agonists (14) Antagonists (35) Activators (180) Modulators (30) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-107414

SKA-121	Activator	99.69%
SKA-121 is a selective K_Ca3.1 activator. SKA-121 exhibits EC₅₀s of 109 nM and 4.4 μM for K_Ca3.1 and K_Ca2.3, respectively.

HY-P0191A

Charybdotoxin TFA	Inhibitor	98.84%
Charybdotoxin TFA, a 37-amino acid peptide, is a K⁺ channel blocker.

HY-104027

ML402	Activator	99.62%
ML402, a thiophene-carboxamide, is a selective K_2P2.1(TREK-1) and K_2P10.1(TREK-2) activator. ML402 is inactive against K_2P4.1(TRAAK).

HY-110162

QO 58		99.01%
QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability.

HY-17504R

Rosuvastatin Calcium (Standard)	Inhibitor
Rosuvastatin (Calcium) (Standard) is the analytical standard of Rosuvastatin (Calcium). This product is intended for research and analytical applications. Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC₅₀ of 195 nM. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

HY-148825

NP10679	Inhibitor	98.40%
NP10679 is a selective, pH dependent GluN2B subunit-specific N-methyl-D-aspartate (NMDA) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC₅₀s of 23 and 142 nM at pH 6.9 and 7.6, respectively. NP10679 is a histamine H1 antagonist and a hERG channel inhibitor with IC₅₀s of 73 and 620 nM, respectively. NP10679 is a reversible inhibitor of human liver CYP enzymes.

HY-B0387A

Ibutilide	Inhibitor	98.98%
Ibutilide (U70226E free base), an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K⁺ current (I_Kr) in AT-1 cells.

HY-P3507

Dalazatide	Inhibitor	99.23%
Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease.

HY-N2877

Annonacin	Inhibitor	98.09%
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W^+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways.

HY-N1504

Loureirin B	Inhibitor	99.95%
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-148304A

VU6036720 hydrochloride	Inhibitor	99.65%
VU6036720 hydrochloride is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 hydrochloride can inhibit Kir4.1/5.1 channels with an IC₅₀ value of 0.24 μM. VU6036720 hydrochloride can be used for the research of brain and kidney.

HY-B0551A

Doxapram hydrochloride hydrate	Inhibitor	99.28%
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.

HY-B0267A

Oxybutynin chloride	Inhibitor	98.49%
Oxybutynin chloride is an oral active and competitive mAChR antagonist with K_is of 14.3 and 5.55 nM for specific [³H]NMS binding in the mouse bladder and cerebral cortex, respectively. Oxybutynin chloride inhibits vascular Kv channels in a manner independent of anticholinergic effect, with an IC₅₀ value of 11.51 μM. Oxybutynin chloride reduces muscle spasm in the bladder and urinary tract, can be used in study of overactive bladder syndrome (OAB). Oxybutynin (chloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-17001A

Flupirtine	Activator	99.98%
Flupirtine(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

HY-15206S1

Glyburide-d₃	Inhibitor	99.64%
Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-145016

HN37	Activator	99.53%
HN37 as a potent and chemically stable antiepileptic agent candidate, with an EC₅₀ of 37 nM for KCNQ2. HN37 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1751B

Quinine sulfate	Inhibitor
Quinidine sulfate is an antiarrhythmic agent. Quinidine sulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate is also a K⁺ channel blocker with an IC₅₀ of 19.9 μM. Quinidine sulfate can be used for malaria research.

HY-13044

ADL-5859 hydrochloride	Inhibitor	99.72%
ADL-5859 hydrochloride (compound 20) is a selective and orally active δ opioid receptor (DOR) agonist with an K_i and an EC₅₀ value of 0.84 and 20 nM, respectively. ADL-5859 hydrochloride also shows inhibitory activity to hERG channel with an IC₅₀ value of 78 μM. ADL-5859 hydrochloride can be used for the research of pain.

HY-P5785A

Heteropodatoxin-2 TFA	Inhibitor
Heteropodatoxin-2 (TFA), a peptides of 30-amino acid, is a heteropodatoxin. Heteropodatoxin-2 blocks Kv4.2 current expressed in Xenopus laevis oocytes in a voltage-dependent manner, with less block at more positive potentials.

HY-44153

KV2 channel inhibitor-1	Inhibitor	98.46%
KV2 channel inhibitor-1 is a selective K_V2 channel inhibitor with IC₅₀s of 0.2 μM and 0.41 μM for K_V2.1 and K_V2.2, respectively. KV2 channel inhibitor-1 possesses good selectivity over K_V1.2 (IC₅₀>10 μM). KV2 channel inhibitor-1 is >10-fold selective over Na_V channels and other K_V channels and displays weak activity on Ca_V channels.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

284compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (881)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (881):